| 发明名称 |
Multiplexed Proteomics and Phosphoproteomics |
| 摘要 |
The disclosure features methods of identifying protein-protein deregulation that include: generating a basal protein-protein interaction network for a plurality of biological samples, the network featuring a set of proteins expressed in the biological samples and concentrations of each member of the set of expressed proteins in each of the biological samples; identifying two associated expressed proteins in the network; for the two associated expressed proteins, comparing correlated relative concentration values of the two proteins in each of the biological samples to identify outliers among a distribution of the relative concentration values; and identifying members of the plurality of biological samples in which deregulation of the two associated expressed proteins occurs based on the outliers. |
| 申请公布号 |
US2017082634(A1) |
申请公布日期 |
2017.03.23 |
| 申请号 |
US201615216617 |
申请日期 |
2016.07.21 |
| 申请人 |
The General Hospital Corporation |
发明人 |
Haas Wilhelm |
| 分类号 |
G01N33/68;C12Q1/48;G06F19/20 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of identifying protein-protein deregulation, the method comprising:
generating a basal protein-protein interaction network for a plurality of biological samples, the network comprising a set of proteins expressed in the biological samples and concentrations of each member of the set of expressed proteins in each of the biological samples; identifying two associated expressed proteins in the network; for the two associated expressed proteins, comparing correlated relative concentration values of the two proteins in each of the biological samples to identify outliers among a distribution of the relative concentration values; and identifying members of the plurality of biological samples in which deregulation of the two associated expressed proteins occurs based on the outliers. |
| 地址 |
Boston MA US |
