| 摘要 |
Disclosed is a cyclic peptide compound of a chemical structure as shown by general formula I, or a pharmaceutically acceptable salt, isomer, racemate, prodrug or solvate thereof. Compared with the positive control (SAHA), the compound has a significant activity in terms of inhibiting the deacetylation of HDAC enzymes (mainly HDAC1, HDAC2, HDAC3, HDAC8 and HDAC11), which are closely related to tumour proliferation and metastasis; and it also has a significant activity in terms of inhibiting the growth of tumour cells. |
