| 发明名称 |
ENGINEERED ANTIBODY CONSTANT DOMAIN MOLECULES |
| 摘要 |
Described herein are engineered antibody constant domain molecules, such as CH2 or CH3 domain molecules, comprising at least one mutation, or comprising at least one complementarity determining region (CDR), or a functional fragment thereof, engrafted in a loop region of the CH2 domain. The CH2 domain molecules described herein are small, stable, soluble, exhibit little to no toxicity and are capable of binding antigen. |
| 申请公布号 |
US2017081393(A1) |
申请公布日期 |
2017.03.23 |
| 申请号 |
US201615367488 |
申请日期 |
2016.12.02 |
| 申请人 |
The U.S.A., as represented by the Secretary, Department of Health and Human Services |
发明人 |
Dimitrov Dimiter S. |
| 分类号 |
C07K16/10;C07K16/00;C07K16/18 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide comprising an immunoglobulin CH2 domain of IgG, IgA or IgD, or a CH3 domain of IgE or IgM, wherein the CH2 domain or CH3 domain comprises an N-terminal truncation of about 1 to about 7 amino acids, and wherein (i) at least one of the loops of the CH2 or CH3 domain is mutated; (ii) at least a portion of a loop region of the CH2 domain or CH3 domain is replaced by a complementarity determining region (CDR), or a functional fragment thereof, from a heterologous immunoglobulin variable domain; or (iii) both, wherein the polypeptide has a molecular weight of less than about 15 kD, and wherein the polypeptide specifically binds an antigen. |
| 地址 |
Bethesda MD US |
