| 摘要 |
The invention provides novel azaborine compounds, methods for their syntheses and functionalization, and various applications thereof. For example, novel azaborine-containing biarylcarboxylic acids and biarylcarboxamides are disclosed herein, which provide the opportunity to be used as therapeutic agents in different diseases. The novel azaborine-containing compounds show unique physical and biological properties when compared to their corresponding all-carbon compounds. Also, disclosed herein are substituted 1,2-dihydro-1,2-azaborine compounds and methods for making the same including methods for the preparation of various substituted azaborines including alkyl, alkenyl, aryl, nitrile, heteroaryl, and fused ring substituents in the presence of B—H, B—Cl, B—O and N—H bonds from Br-substituted azaborines as well as the synthesis of new fused BN-heterocycles. |
| 主权项 |
1. A compound having the structural Formula (I): wherein
R1 is H, or an optionally substituted alkyl, aryl, or silane group;R2 is H, a halogen, or an optionally substituted aryl, alkyl, alkenyl, alkynyl, alkoxy, amino, alcohol, or thio group; andeach of R3, R4, R5 and R6 is independently H, a halogen, or an optionally substituted alkyl, alkoxy, aryl, alkenyl, alkynyl, heteroaryl, phosphinyl, amino, amide, silyl, thio, sunlfonyl, carbonyl, ester, or ketone group, or a pharmaceutically acceptable salt or ester thereof. |
