| 发明名称 |
Method for Adjusting the Release of Active Agent in a Transdermal Delivery system |
| 摘要 |
Use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, wherein the inner phase comprises the additive and an active agent dissolved therein, wherein the additive has a higher affinity to water than to the active agent, for the control of the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, wherein the maintenance of the permeation rate is proportional to the amount of active agent in the biphasic layer. |
| 申请公布号 |
US2017079932(A1) |
申请公布日期 |
2017.03.23 |
| 申请号 |
US201515312542 |
申请日期 |
2015.05.20 |
| 申请人 |
LTS Lohmann Theraple-Systeme AG ;UCB PHARMA GMBH |
发明人 |
Emgenbroich Marco;Leonhard Johannes Josef;Wolff Hans-Michael |
| 分类号 |
A61K9/70;A61K31/381;A61K47/32;A61K9/00 |
主分类号 |
A61K9/70 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase,wherein the inner phase comprises
the additive and an active agent dissolved therein, wherein the additive has a higher affinity to water than to the active agent, for the control of the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, wherein the maintenance of the permeation rate is proportional to the amount of active agent in the biphasic layer. |
| 地址 |
Andernach DE |
