发明名称 |
DUAL VARIABLE DOMAIN IMMUNOCONJUGATES AND USES THEREOF |
摘要 |
Dual variable domain (DVD) immunoconjugates and uses thereof are provided. Aspects of the subject immunoconjugates include a DVD immunoglobulin molecule having a first and a second variable domain, and a cargo moiety (e.g., a drug moiety) that is covalently conjugated to the second variable domain via a linker. Methods of making and using the subject immunoconjugates in the prevention and/or treatment of cancer and other diseases are also provided. |
申请公布号 |
WO2017049139(A2) |
申请公布日期 |
2017.03.23 |
申请号 |
WO2016US52214 |
申请日期 |
2016.09.16 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
RADER, Christoph;NANNA, Alex R.;ROUSH, William R. |
分类号 |
C07K19/00 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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