发明名称 |
CELL LINE, SYSTEM AND METHOD FOR OPTICAL CONTROL OF SECONDARY MESSENGERS |
摘要 |
A variety of methods, devices and compositions are implemented for light-activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence for expressing a chimeric light responsive membrane protein (e.g., rhodopsin) is modified with one or more heterologous receptor subunits {e.g., an adrenergic receptor (alpha1, Beta2)}. The light responsive membrane protein is expresses in a cell for producing a secondary messenger in response to light. |
申请公布号 |
US2017081388(A1) |
申请公布日期 |
2017.03.23 |
申请号 |
US201615258876 |
申请日期 |
2016.09.07 |
申请人 |
The Board of Trustees of the Leland Stanford Junior University |
发明人 |
Deisseroth Karl;Airan Raag D. |
分类号 |
C07K14/72;C12N5/0793;C12N13/00;A61B5/00;A61K48/00;A61K49/00;A61N5/06;G01N33/50;A61K41/00 |
主分类号 |
C07K14/72 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
Stanford CA US |