PEPTIDES AS OXYTOCIN AGONISTS

摘要

The present compounds compounds are oxytocin receptor agonists for the treatment of autism, stress, including post traumatic stress disorder, anxiety, including anxiety disorders and depression, schizophrenia, psychiatric disorders and memory loss, alcohol withdrawal, drug addiction and for the treatment of Prader-Willi Syndrome.

主权项

1. A compound of formula wherein
R1 is hydrogen, lower alkyl or cycloalkyl;R2 is hydrogen or
R1 and R2 may form together with the N and C atom to which they are attached a pyrrolidine ring optionally substituted by one or two F-atoms or by hydroxy, or may form an azetidine or a piperazine ring;R3 is hydrogen, lower alkyl, lower alkyl substituted by hydroxy, —(CH2)2C(O)NH2, benzyl, phenyl, —CH2-five membered aromatic heterocyclic group, CH2-indolyl, —CH2-cycloalkyl, cycloalkyl or —(CH2)2-S-lower alkyl;R3′ is hydrogen or lower alkyl; orX is —C(O)—CHR4—CHR4′—C(O)—NH—CH2—R4/R4′ are hydrogen or one of R4 or R4′ is amino:o is 0 or 1; or a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and/or optical isomers thereof.