DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA

摘要

Provided are novel compounds of Formula (I):;;pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

主权项

1. A compound of the Formula: or a pharmaceutically acceptable salt thereof, wherein
R2 is (C1-C3)alkyl, hydroxy(C1-C3)alkyl, halo(C1-C3)alkyl, benzyl, (C1-C3)alkoxy(C1-C3)alkyl, tetrahydropyranyl, or —CH2-tetrahydropyranyl;R3 and R4 are each independently hydrogen or methyl;Cy1 is phenyl or pyridyl, each substituted with (C1-C3)alkylsulfonyl; andCy2 is hydrogen, halo(C1-C3)alkyl, cyclohexyl, or tetrahydropyranyl, wherein the cyclohexyl and tetrahydropyranyl are each optionally substituted with one or more groups selected from halo(C1-C3)alkyl and C1-C3(alkoxy).