| 摘要 |
The invention relates to a system of fluidic valves and pumps and associated fluidic channels integratable into a bio-object microfluidics module. The module can include input and output buses; upstream and downstream interconnection bus control valves (CVs) coupled to the input and output buses, respectively. It may include arterial, venous, wash and waste bus lines, each connecting between the upstream and downstream interconnection bus CVs. It may also include an input CV connecting to the arterial bus line, upstream interconnection bus CV, bio-object and inlets, and an output CV connecting to the bio-object, input CV, downstream interconnection bus CV and outlets; and a pump connecting between the input CV and bio-object. The system of fluidic valves and pumps can be arranged to provide MicroFormulator functionality enabling precise mixtures of drugs, chemicals, or biochemicals to be delivered in a time-dependent fashion to biological entities housed in individual wells or chambers. |
| 主权项 |
1. An integrated bio-object microfluidics module, the bio-object including an organ, a group of cells, tissues, or the like, comprising:
an input bus, and an output bus, being connectable to an interface that allows the integrated bio-object microfluidics module to be connected to another integrated bio-object microfluidics module, or other microfluidic module of a similar design; an upstream interconnection bus control valve fluidic coupled to the input bus, and a downstream interconnection bus control valve fluidic coupled to the output bus; an arterial bus line, a venous bus line, a wash bus line, and a waste bus line, each fluidically connecting between the upstream interconnection bus control valve and the downstream interconnection bus control valve; an input control valve fluidically connecting to the arterial bus line, the upstream interconnection bus control valve, the bio-object and a plurality of inlets, and an output control valve fluidically connecting to the bio-object, the input control valve, the downstream interconnection bus control valve and a plurality of outlets; a pump fluidically connecting between the input control valve and the bio-object; wherein the plurality of inlets is adapted for providing a plurality of fluids, and the plurality of outlets is adapted for collecting waste and sample for analysis; and wherein each of the input control valve, the output control valve, the upstream interconnection bus control valve and the downstream interconnection bus control valve comprises a plurality of control ports, each control port being individually controllable in an open state in which a flow of fluid is allowed or a closed state in which a flow of fluid is occluded, such that the integrated bio-object microfluidics module is selectively operable in one of a Run Isolated Mode, a Run Interconnected Mode, and a Sterilize/Wash mode. |
