发明名称 |
An improved expression cassette for packaging and expression of variant Factor VIII for the treatment of hemostasis disorders |
摘要 |
Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over wild-type Factor VIII proteins, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced activity over wild-type Factor VIII proteins and are packaged more efficiently into viral vectors. |
申请公布号 |
AU2015301598(A1) |
申请公布日期 |
2017.03.23 |
申请号 |
AU20150301598 |
申请日期 |
2015.08.13 |
申请人 |
Elkouby, Liron;Sabatino, Denise;The Children's Hospital of Philadelphia;High, Katherine |
发明人 |
Sabatino, Denise;High, Katherine A.;Elkouby, Liron |
分类号 |
C07K14/755;A61K38/37;C12N15/00 |
主分类号 |
C07K14/755 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|