Disclosed herein are analytical methods to predict or determine a subject's phenotype burden and/or genomic load from the subject's genome sequence variants. The disclosed methods may report a dynamically ordered list of genes or genomic regions responsible for each of one or more phenotypes. Also disclosed herein are analytical methods to convert the phenotype burden and/or genomic load into a probability or risk profile or percentile for a certain phenotype or one or more phenotypes among a plurality of phenotypes, which may be compared to a reference population.
