COMPOSITIONS AND METHOD FOR REGULATING ADIPOSE TISSUE LIPOLYSIS, INSULIN-RESISTANCE, AND HYPERGLYCEMIA

摘要

The present application discloses compositions and methods useful for controlling blood glucose and insulin resistance during the acute stress response. It is shown that Atglistatin can attenuate glucose excursions and insulin resistance arising from surgical procedures. It is further disclosed herein that Atglistatin is useful for inhibiting and preventing hyperglycemia and insulin resistance in many acute stress conditions, including, but not limited to, surgery, trauma/hemorrhage, burns, sepsis, myocardial infarction, and stroke.