COMPOSITIONS AND METHODS FOR ANALYTE DETECTION USING NANOSWITCHES

摘要

Provided herein are nucleic acid-based nanoswitches that can detect specific nucleic acids and other analytes types by for example a simple gel electrophoresis readout. Binding of the target to the nanoswitches induces a conformation change from a linear, open conformation to a looped, closed conformation. These nanoswitches may be used in diagnostic assays such as nucleic acid- based diagnostic assays, to detect, measure and/or purify a variety of targets including low abundance targets.