METHODS AND SYSTEMS FOR NEAR-SIMULTANEOUS MEASUREMENT OF NEURON ACTIVITY AND NEUROTRANSMITTER CONCENTRATION

摘要

Methods and systems providing near-simultaneous measurements of neurotransmitter release and neural activity are presented. The system has a voltammetry probe for neurotransmitter recordings and an electrophysiology probe, including a relay switch, for neural ensemble recordings. The electrophysiology circuitry is isolated from the applied voltage of the voltammetry prove when the switch is open. The voltammetry probe features a novel grounding/referencing scheme that applies a voltage to the working electrode and grounds the reference electrode. This configuration may help reduce interference between electrophysiological (voltage/action potential) and voltammetric recordings.