ACID ALPHA-GLUCOSIDASE AND A β-2 AGONIST FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDER

摘要

The present disclosure is directed to methods of treating a lysosomal storage disorder by administering a therapeutic agent as an adjunctive therapy to lysosomal enzyme replacement therapy. Other embodiments are directed to methods of increasing expression of a receptor for a lysosomal enzyme and methods of treating a lysosomal storage disorder. Some embodiments are directed to a method of treating a glycogen storage disease II in an individual by administering to the individual an acid alpha-glucosidase and a β2 agonist. Some embodiments herein are directed to a method of treating a glycogen storage disease II by administering (1) rhGAA; and (2) clenbuterol.