发明名称 |
AAV virions with decreased immunoreactivity and uses therefor |
摘要 |
Methods of making and using recombinant AAV virions with decreased immunoreactivity are described. The recombinant AAV virions include mutated capsid proteins or are derived from non-primate mammalian AAV serotypes and isolates that display decreased immunoreactivity relative to AAV-2. |
申请公布号 |
EP2657248(B1) |
申请公布日期 |
2017.03.22 |
申请号 |
EP20130163182 |
申请日期 |
2004.06.21 |
申请人 |
Genzyme Corporation |
发明人 |
Arbetman, Alejandra Elena;Colosi, Peter C.;Lochrie, Michael A;Surosky, Richard T |
分类号 |
C07K1/00;A61K;C07K14/00;C07K14/015;C07K17/00;C12N15/00;C12N15/09;C12N15/63;C12N15/70;C12N15/74;C12N15/864 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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