发明名称 |
IMPROVED LIGHT-EMITTING MOLECULES |
摘要 |
Disclosed are luciferase polypeptides with improved light-emitting activity and their encoding nucleic acids. These molecules are useful in a range of assays including luciferase-based gene reporter assays, bioluminescence resonance energy transfer assays, protein complementation assays and other applications in which luciferase enzymes are utilized as detectable and/or quantifiable labels. Also disclosed are methods and compositions for increasing the sensitivity and/or improving the kinetics of luciferase-catalyzed reactions as well as decreasing the impact of undesirable variables. |
申请公布号 |
EP2646548(B1) |
申请公布日期 |
2017.03.22 |
申请号 |
EP20110845321 |
申请日期 |
2011.12.05 |
申请人 |
Gene Stream Pty Ltd. |
发明人 |
DALY, John;BROWNRIGG, Leon, Michael;TIAO, Jim Yu-Hsiang |
分类号 |
C12N9/02;C07K1/00;C07K2/00;C12Q1/66;G01N33/52 |
主分类号 |
C12N9/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|