发明名称 |
T CELL-REDIRECTED ANTIGEN-BINDING MOLECULE FOR CELLS HAVING IMMUNOSUPPRESSION FUNCTION |
摘要 |
It was discovered that antigen-binding molecules comprising (i) a domain that binds to a molecule expressed on the surface of cells having immune response-suppressing functions, and (ii) a T cell receptor complex-binding domain exhibit more superior antitumor effects than conventional antigen-binding molecules by crosslinking T cells with cells having immune response-suppressing functions, and damaging the cells having immune response-suppressing functions. |
申请公布号 |
EP3144388(A1) |
申请公布日期 |
2017.03.22 |
申请号 |
EP20150793048 |
申请日期 |
2015.05.13 |
申请人 |
Chugai Seiyaku Kabushiki Kaisha;Osaka University |
发明人 |
IGAWA, Tomoyuki;ISHIGURO, Takahiro;SAKAGUCHI, Shimon;NISHIKAWA, Hiroyoshi |
分类号 |
C12N15/00;A61K39/395;A61P15/00;A61P35/00;A61P35/02;C07K16/28;C07K16/46 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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