| 摘要 |
An isothermal titration micro calorimetry (ITC) system (300), comprising: a microcalorimeter (20), an automatic pipette assembly (30), a pipette translation unit (310) and a wash station.. The microcalorimeter (20) has a sample cell (50) and a reference cell (40), the sample cell (50) accessible via a sample cell stem (180) and the reference cell accessible via a reference cell stem (170). The automatic pipette assembly (30) comprise a syringe (200) with a titration needle (210) arranged to be inserted into the sample cell (50) for supplying titrant and a fill port (500) at an upper section of the syringe (200), providing fluidic contact with the syringe cavity when the plunger (230) is positioned above the fill port (500). The pipette assembly (30) also comprises an activator (220) for driving a plunger (230) in the syringe (200). The pipette translation unit (310) comprises a pipette arm (380) that is supported for rotation about an axis (A), supports the pipette assembly (30) at its other end and is further arranged to move the pipette assembly vertically. The pipette translation unit (310) is arranged to place the pipette assembly (30) in position for titration, washing and filling operations. The wash station is for the titrant needle (210). |
