DIAGNOSTIC TEST AND TREATMENT/PREVENTION OF ALZHEIMER'S DISEASE

摘要

The present invention includes a method for diagnosis and treatment and prevention of Alzheimer's Disease comprising obtaining a biological sample from a subject suspected of having Alzheimer's Disease; determining the level of expression of HSP 27, wherein a statistically significant increase in HSP27 protein expression in the sample as compared to a sample from a non-Alzheimer's patient is indicative that the subject has Alzheimer's Disease; and modifying the treatment of the subject as a result of the detection of Alzheimer's Disease by providing the subject with standard therapy or a single vector expressing an A&bgr;42 trimer peptide and optionally the addition of an A&bgr;42 peptide, which elicits an immune reaction against the A&bgr;42 peptide, thereby preventing the accumulation of A&bgr;42 peptide and therefore preventing or treating Alzheimer's Disease.