Oxygen enhancing membrane systems for implantable devices

摘要

The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

主权项

1. A system for continuous in vivo measurement of a glucose concentration in a host, the system comprising:
an implantable sensor configured to generate in vivo a signal indicative of a concentration of glucose in a host; a membrane located over the sensor, the membrane comprising:
a first domain comprising an enzyme configured to catalyze a reaction that has glucose as a reactant; anda second domain configured to control a flux therethrough of glucose to the first domain, wherein the second domain comprises a polyurethane-containing material having an oxygen permeability of from about 3 Barters to about 1000 Barters; and sensor electronics configured to operatively connect with the implantable sensor and to process the signal and determine a glucose concentration value.