发明名称 |
Nanoparticle-peptide compositions |
摘要 |
The present invention provides nanoparticles and compositions comprising such nanoparticles, as well as methods for intracellular delivery of peptides, and methods of producing nanoparticles and related products. The nanoparticles comprise a core comprising a metal and/or a semiconductor atom; and a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker, and wherein at least a second ligand of said plurality comprises a peptide of choice that is covalently linked to the core via a second linker. The second linker comprises a peptide portion and a non-peptide portion, wherein said peptide portion of said second linker comprises the sequence X1X2Z1, wherein: X1 is an amino acid selected from A and G; X2 is an amino acid selected from A and G; and Z1 is an amino acid selected from Y and F. |
申请公布号 |
US9598479(B2) |
申请公布日期 |
2017.03.21 |
申请号 |
US201214343083 |
申请日期 |
2012.09.07 |
申请人 |
Midatech Ltd. |
发明人 |
Rademacher Thomas;Williams Phillip |
分类号 |
A61K47/48;C07K14/47;C07K7/06;C07K7/08;C07K14/77;A61K38/38;A61K39/00 |
主分类号 |
A61K47/48 |
代理机构 |
Dann, Dorfman, Herrell and Skillman |
代理人 |
Hagan Patrick J.;Dann, Dorfman, Herrell and Skillman |
主权项 |
1. A nanoparticle comprising:
(i) a core comprising a metal and/or a semiconductor atom; (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein at least a first ligand of said plurality comprises a carbohydrate moiety that is covalently linked to the core via a first linker or comprises glutathione, and wherein at least a second ligand of said plurality comprises a peptide of choice that is covalently linked to the core via a second linker, said second linker comprising:
a peptide portion and a non-peptide portion, wherein said peptide portion of said second linker comprises the sequence FLAAY (SEQ ID NO: 1). |
地址 |
Abingdon, Oxfordshire GB |