Methods of treating metabolic disorders

摘要

The present invention addresses the problem of providing a means which is effective for the induction of the differentiation of a brown adipocyte and therefore enables a brown adipocyte to be used for and applied to, for example, the prevention/treatment of obesity or metabolic syndrome. Provided is a brown adipocyte differentiation-inducing agent containing, as an active ingredient, (1) CREG1 protein or (2) an expression vector carrying CREG1 gene.

主权项

1. A method of treating a metabolic disorder or a related disease thereof, including a step of administrating a therapeutically effective amount of a medicament comprising the following (1) or (2) as an active ingredient to a patient with the metabolic disorders or the related disease thereof:
(1) cellular repressor of E1A-stimulated genes 1 (CREG1) protein; (2) an expression vector encoding the CREG1 gene, wherein the metabolic disorders or related disease thereof is obesity, diabetes, lipid abnormality, arteriosclerosis, metabolic syndrome, or other disorders that would benefit from loss of weight.