Composite antigenic sequences and vaccines

摘要

The invention relates to composite antigens comprising a peptide with contiguous amino acid sequence derived from a plurality of antigenic epitopes of one or more pathogens that induces an immune response in a mammal that is protective against infection by the one or more pathogens. In addition, the invention relates to vaccines comprising composite antigens and to method for treating and preventing an infection.

主权项

1. A composite antigen comprising an amino acid sequence containing amino acids that are in common between sequences of epitopes of multiple conserved regions, and amino acids that differ between the sequences of epitopes of multiple conserved regions, wherein the amino acid sequence has the formula An1BCAn2, wherein A represents the amino acids that are in common between sequences of epitopes of multiple conserved regions, B and C represent the sequences of amino acids that differ between the sequences of epitopes of multiple conserved regions, wherein A, B, and C are naturally occurring amino acids, n1 and n2 total to less than 25, and the number of B and C amino acids is each less than 3, which comprises SEQ ID No. 21, 22, 54, 55, 58, or 59.