β-Hydroxy-β-methylbutyric (HMB) acid purification method

摘要

The present invention relates generally to the field of chemical synthesis. Specifically, the present invention relates to a method for purification of β-hydroxyl-β-methyl butyrate comprising (1) neutralizing a crude β-hydroxyl-β-methyl butyrate; (2) cooling and crystallizing the crude β-hydroxyl-β-methyl butyrate solution to create a β-hydroxyl-β-methyl butyrate salt; (3) dissolving and acidifying the salt; and (4) extracting the resultant high purity β-hydroxyl-β-methyl butyrate. Additionally, the present invention relates to a method of obtaining high purity β-hydroxyl-β-methyl butyrate at normal temperature and vacuum conditions.

主权项

1. A method for purifying β-hydroxyl-β-methyl butyrate, comprising:
(a) neutralizing a crude β-hydroxyl-β-methyl butyrate with a base; (b) crystallizing, centrifuging, and drying the crude β-hydroxyl-β-methyl butyrate to obtain a crystallized product containing a salt of β-hydroxyl-β-methyl butyrate; (c) adding an inorganic acid to the salt of β-hydroxyl-β-methyl butyrate product for dissolution and acidification; and (d) extracting β-hydroxyl-β-methyl butyrate from the dissolved and acidified salt of β-hydroxyl-β-methyl butyrate to obtain β-hydroxyl-β-methyl butyrate; wherein the purity of the β-hydroxyl-β-methyl butyrate is about 97 percent or greater.