发明名称 |
MULTIFUNCTIONAL ANTIBODY CONJUGATES |
摘要 |
The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL?) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention. |
申请公布号 |
CA2804185(C) |
申请公布日期 |
2017.03.21 |
申请号 |
CA20112804185 |
申请日期 |
2011.07.11 |
申请人 |
COVX TECHNOLOGIES IRELAND LIMITED |
发明人 |
BHAT, ABHIJIT SURESH;BRADSHAW, CURT WILLIAM;LAURENT, OLIVIER ALEXANDRE;PRESTON, RICHARD RYAN;TUMELTY, DAVID;WOOD, LAUREN DIANE;YU, WEI HONG;LEE, ALICE |
分类号 |
A61K47/68;A61P35/00;C07K16/28 |
主分类号 |
A61K47/68 |
代理机构 |
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代理人 |
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地址 |
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