| 主权项 |
1. A method of modulating an immune response in an individual, the method comprising administering to the individual a compound according to formula (I), or a physiologically acceptable salt, solvate, ester or other physiologically functional derivative thereof: wherein, A is an aryl group, optionally substituted by at least one substituent; where said at least one substituent is independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxy, alkyloxycarbonyl hydroxyl, amino, nitro, alkyloxy, perfluoroalkloxy, —SH, alkylthio, formyl, cyano, carbamoyl, an amide, halo, a ketone, —S(O)NR12R13 or —S(O)R14; wherein R12, R13 or R14 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, or substituted or unsubstituted monocyclic or polycyclic aryl or heteroaryl; wherein when one of R5, R6 and R7 is absent, the nitrogen atom to which they are bonded is not charged or when R5, R6 and R7 are present together the nitrogen atom to which they are bonded is positively charged and there is present a negatively charged counter ion; R3, R4, R5, R6 and R7 when present are independently, for each occurrence, selected from the group consisting of H, alkyl, alkenyl and alkynyl; and optionally, two or more of R5, R6 and R7 are bonded together to form a monocyclic or bicyclic ring with the nitrogen atom to which they are bonded, wherein when R3, R4, R5, R6 and R7 are independently an alkyl, alkenyl or alkynyl group, and each group is optionally substituted with an amine; and n is an integer having a value of from 1 to 6, in an amount sufficient to modulate the immune response in the individual. |
