Treatment of cognitive disorders associated with abnormal dendritic spines using PKC activators

摘要

The present disclosure provides methods of treating a cognitive disorder associated with abnormal dendritic spines, such as Fragile X Syndrome, Fragile X Associated Tremor/Ataxia Syndrome, autism, or mental retardation, using PKC activators.

主权项

1. A method of treating a cognitive disorder associated with abnormal dendritic spines in a subject in need thereof comprising administering to the subject an effective amount of a PKC activator in a pharmaceutically acceptable carrier
wherein PKC is activated without being downregulated, wherein the PKC activator (a) improves cognitive function, (b) restores the morphology of dendritic spines in neurons, and/or (c) increases the amount of synaptophysin, and wherein the cognitive disorder is chosen from Fragile X syndrome, Fragile X Associated Tremor/Ataxia Syndrome, autism, and mental retardation.