| 发明名称 | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof | ||
| 摘要 | Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclosed. | ||
| 申请公布号 | US9597292(B2) | 申请公布日期 | 2017.03.21 |
| 申请号 | US201313973456 | 申请日期 | 2013.08.22 |
| 申请人 | XenoPort, Inc. | 发明人 | Karaborni Sami;Ma Sarina Grace Harris;Mao Chen;Chong Ching Wah;Freed Peter Robert Prinz;Ciper Mesut;Krenzlin Stefanie;Wustrow David J.;Virsik Peter A. |
| 分类号 | A61K9/48;A61K9/14;A61K9/16;A61K9/28;A61K9/20;A61K31/225;A61K31/215;A61K31/27;A61K31/5375 | 主分类号 | A61K9/48 |
| 代理机构 | Polsinelli PC | 代理人 | Polsinelli PC |
| 主权项 | 1. A method of making (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate-containing pharmaceutical pellets comprising: mixing the (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate in an aqueous medium to form a wet mass; adding acetic acid to the wet mass to form a mixture; maintaining the mixture at a pH at or below 3.8; and forming pellets. | ||
| 地址 | Redwood City CA US | ||