发明名称 |
T-LYMPHOCYTE-TARGETED BIODEGRADABLE NANOPARTICLES COMPRISING LEUKAEMIA INHIBITORY FACTOR |
摘要 |
A composition for modulating the immune response in a mammal comprising a pharmaceutically acceptable carrier solution and a plurality of biodegradable nanoparticles, wherein the nanoparticles comprise a targeting moiety that is able to bind selectively to the surface of a T lymphocyte cell and/or of a vascular endothelial cell and wherein the nanoparticles further comprise leukaemia inhibitory factor (LIF). Nanoparticle-mediated targeted delivery of LIF can be used a means to guide tolerogenesis in a patient and has immediate clinical application for recipients of organ grafts and also for patients suffering from autoimmune disease. |
申请公布号 |
CA2740960(C) |
申请公布日期 |
2017.03.21 |
申请号 |
CA20082740960 |
申请日期 |
2008.10.24 |
申请人 |
METCALFE, SUSAN MARIE;YALE UNIVERSITY |
发明人 |
METCALFE, SUSAN MARIE;FAHMY, TAREK M. |
分类号 |
A61K9/127;A61K9/51;A61P37/00;A61P37/02;A61P37/06 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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