Imidazopyridazine compounds

摘要

The present invention is directed to compounds of Formula I:;
or a pharmaceutically acceptable salt thereof, wherein the substituents R1, R3, R6, R7, and b are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of preparing the compounds.

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from the group consisting of —(CH2)m—(C3-C8)cycloalkyl, —(CH2)m-(4- to 10-membered)heterocycloalkyl, —(CH2)m—(C6-C10)aryl and —(CH2)m-(5- to 14-membered)heteroaryl, and, where chemically permissible, the (C3-C8)cycloalkyl, (4- to 10-membered)heterocycloalkyl, (C6-C10)aryl and (5- to 14-membered)heteroaryl moieties are optionally substituted with one to five R2;when present, each R2 is independently selected from the group consisting of halogen, oxo, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, —N(R4)(R5), —N(R4)(C═(O)R5), —C(═O)N(R4)(R5), —C(═O)—O—N(R4)(R5), —C(═O)—R4, —C(═O)—OR4, and optionally substituted (C3-C8)cycloalkyl;when present, each R3 is independently selected from the group consisting of halogen, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, —N(R4)(R5), —N(R4)(C═(O)R5), —C(═O)N(R4)(R5), —C(═O)—O—N(R4)(R5), —C(═O)—R4, and —C(═O)—OR4;R4 and R5 are each independently selected from the group consisting of hydrogen and optionally substituted (C1-C6)alkyl;R6 and R7 are each independently selected from the group consisting of hydrogen, optionally substituted (C1-C6)alkyl, —(CH2)n—(C3-C8)cycloalkyl, —(CH2)n-(4- to 10-membered) heterocycloalkyl, —(CH2)n—(C6-C10)aryl, and —(CH2)n-(5- to 10-membered)heteroaryl, and where chemically permissible, the (C3-C8)cycloalkyl, (4- to 10-membered)heterocycloalkyl, (C6-C10)aryl, and (5- to 10-membered)heteroaryl are optionally substituted with one to five R8; orR6 and R7 taken together with the nitrogen to which they are attached form a (4- to 10-membered)heterocycloalkyl, and where chemically permissible, the (4- to 10-membered)-heterocycloalkyl is optionally substituted with one to five R9;when present, each R8 is independently selected from the group consisting of halogen, oxo, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, —N(R4)(R5), —N(R4)(C═(O)R5), —C(═O)N(R4)(R5), —C(═O)—O—N(R4)(R5), —C(═O)—R4, and —C(═O)—OR4;when present, each R9 is independently selected from the group consisting of halogen, oxo, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, —N(R4)(R5), —N(R4)(C═(O)R5), —C(═O)N(R4)(R5), —C(═O)—O—N(R4)(R5), —C(═O)—R4, and —C(═O)—OR4;b is represented by an integer selected from 0, 1, 2, or 3;m is represented by an integer selected from 0, 1, or 2; andn is represented by an integer selected from 0, 1, 2, 3 or 4.