| 发明名称 | Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases | ||
| 摘要 | The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. | ||
| 申请公布号 | US9598338(B2) | 申请公布日期 | 2017.03.21 |
| 申请号 | US201314390960 | 申请日期 | 2013.04.08 |
| 申请人 | UNIVERSITY OF SOUTH FLORIDA;THE DEPARTMENT OF VETERANS AFFAIRS | 发明人 | Dickey Chad;Jinwal Umesh;Calcul Laurent;Baker Bill J.;Lebar Matthew |
| 分类号 | A61K31/05;A61P25/28;C07C43/23;C07C69/28;C07C43/21;C07C43/215;C07C47/277;A61K31/11;A61K31/121 | 主分类号 | A61K31/05 |
| 代理机构 | Saliwanchik, Lloyd & Eisenschenk | 代理人 | Saliwanchik, Lloyd & Eisenschenk |
| 主权项 | 1. A method of reducing intracellular tau levels, wherein said method comprises administering, to cells comprising protein tau, an effective amount of a compound of formula A, formula C to formula F, or formula J to formula L: wherein each of R1-R4 of formula A, formula C, formula D, formula F, formula J, formula K, and formula L is, independently, —H or any group that forms an ester or ether bond; wherein each of R1-R8 of formula E is, independently, H or any group that forms an ester or ether bond; whereby intracellular tau level is reduced. | ||
| 地址 | Tampa FL US | ||