| 发明名称 | Methods for expressing a polynucleotide of interest in the retina of a subject | ||
| 摘要 | Provided herein are methods for expressing a polynucleotide of interest in the retina of a subject. In particular, a method for expressing a polynucleotide of interest in the retina of a subject comprising the step consisting of injecting into the vitreous an amount of a vector containing the polynucleotide of interest in combination with an amount of an inhibitor of Dp71 expression is provided. | ||
| 申请公布号 | US9597415(B2) | 申请公布日期 | 2017.03.21 |
| 申请号 | US201414900350 | 申请日期 | 2014.06.27 |
| 申请人 | INSERM (INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 发明人 | Dalkara Deniz;Rendon Fuentes Alvaro;Sahel Jose Alain;Vacca Ophelie |
| 分类号 | A61K48/00;C07K14/47;C12N15/86;A61K9/00;A61K31/713;A61K38/46;C12N7/00;C12N15/113 | 主分类号 | A61K48/00 |
| 代理机构 | Whitham, Curtis & Cook, P.C. | 代理人 | Whitham, Curtis & Cook, P.C. |
| 主权项 | 1. A method for enhancing delivery of a polynucleotide of interest in the retina of a subject affected with or likely to be affected with a retinal disease comprising the step of injecting into the vitreous of said subject an amount of a vector containing the polynucleotide of interest in combination with an amount of an inhibitor of Dp71 expression, wherein the inhibitor of Dp71 expression is a siRNA. | ||
| 地址 | Paris FR | ||