Quinazolinone analogs and use of quinazolinone analogs for treating or preventing certain viral infections

摘要

Provided is a process for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus. The process includes administering to the subject a therapeutically effective amount of at least one compound represented by the formula: (Formula (I));

主权项

1. A process for treating or preventing a viral infection in a subject from Hepatitis C Virus, by administering to the subject a therapeutically effective amount of at least one compound selected from the group consisting of 2-[3-(3,4-dichlorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-(4-phenyl(1,3-thiazol-2-yl))acetamide; N-benzothiazol-5-yl-2-[3-(3,4-dichlorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]acetamide; 2-[3-(3,4-dichlorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-(4-methyl(1,3-thiazol-2-yl))acetamide; N-(2,3-dihydro-1H-inden-5-yl)-2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)acetamide; 2-[3-(3-chloro-4-fluorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-5-ylacetamide; 2-[3-(3,4-dichlorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-5-ylacetamide; 2-(5-fluoro-4-oxo-3-phenyl(3-hydroquinazolin-2-ylthio))-N-indan-5-ylacetamide; N-indan-5-yl-2-(8-methyl-4-oxo-3-phenyl(3-hydroquinazolin-2-ylthio))acetamide; N-indan-5-yl-2-(8-methoxy-4-oxo-3-phenyl(3-hydroquinazolin-2-ylthio))acetamide; 2-[3-(3,4-dichlorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-4-ylacetamide; N-(2H-benzo[d]1,3-dioxolen-5-yl)-2-[3-(3,4-dichlorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]acetamide; 3-[3-(3-chloro-4-fluorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-5-ylpropanamide; 2-[3-(3-chloro-4-fluorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-4-ylacetamide; N-(2H-benzo[3,4-d]1,3-dioxolan-5-yl)-2-[3-(3-chloro-4-fluorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]acetamide; 2-[3-(3,4-difluorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-4-ylacetamide; 2-[3-(3,4-difluorophenyl)-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-5-ylacetamide; 2-(5-fluoro-4-oxo-3-phenyl(3-hydroquinazolin-2-ylthio))-N-(1,2,3,4-tetrahydronaphthyl)acetamide; 2-[3-(4-chloro-3-fluorophenyl)-5-fluoro-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-5-ylacetamide; 2-[5-fluoro-4-oxo-3-(3,4,5-trifluorophenyl)(3-hydroquinazolin-2-ylthio)]-N-indan-5-ylacetamide; and 2-[3-(3,4-dichlorophenyl)-5-fluoro-4-oxo(3-hydroquinazolin-2-ylthio)]-N-indan-5-ylacetamide; pharmaceutically acceptable salts thereof; solvates thereof and deuterated forms thereof.