发明名称 |
ANTIBODIES TO COAGULATION FACTOR XIA AND USES THEREOF |
摘要 |
In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided. |
申请公布号 |
WO2017015619(A8) |
申请公布日期 |
2017.03.16 |
申请号 |
WO2016US43703 |
申请日期 |
2016.07.22 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;PFIZER INC. |
发明人 |
MIKITA, Thomas;ELY, Lauren K.;GAO, Huilan;KIM, Yun;RONDON, Isaac J.;DAVID, Tovo;COUGHLIN, Shaun R. |
分类号 |
A61K39/395;A61P7/02;C07K16/36 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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