METHODS FOR TREATING RELAPSING FORMS OF MULTIPLE SCLEROSIS

摘要

Disclosed herein are anti-RGMa antibodies and methods of using these antibodies to treat multiple sclerosis, including relapsing forms of multiple sclerosis such as relapsing-remitting multiple sclerosis or relapsing-secondary progressive multiple sclerosis.

主权项

1. A method of treating a relapsing form of multiple sclerosis in a subject in need thereof, the method comprising administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds Repulsive Guidance Molecule A (RGMa), wherein the antibody or antigen binding fragment comprises
(a) a variable heavy chain comprising a complementarity determining region (CDR)-1 comprising an amino acid sequence of SEQ ID NO:2, a CDR-2 comprising an amino acid sequence of SEQ ID NO:3, and a CDR-3 comprising an amino acid sequence of SEQ ID NO:4; and (b) a variable light chain comprising a CDR-1 comprising an amino acid sequence of SEQ ID NO:6, a CDR-2 comprising an amino acid sequence of SEQ ID NO:7, and a CDR-3 comprising an amino acid sequence of SEQ ID NO:8.