FACTOR VIII CHIMERIC PROTEINS AND USES THEREOF

摘要

The present invention provides a chimeric protein comprising a first polypeptide which comprises a FVIII protein and a first Ig constant region or a portion thereof and a second polypeptide which comprises a VWF protein comprising the D′ domain and D3 domain of VWF, a XTEN sequence having less than 288 amino acids in length, and a second Ig constant region or a portion thereof, wherein the first polypeptide and the second polypeptide are associated with each other. The invention also includes nucleotides, vectors, host cells, methods of using the chimeric proteins.

主权项

1. A chimeric protein comprising (i) a first polypeptide which comprises a Factor VIII (“FVIII”) protein fused to a first immunoglobulin (“Ig”) constant region or a portion thereof and (ii) a second polypeptide which comprises a von Willebrand Factor (“VWF”) protein comprising a D′ domain and a D3 domain of VWF fused to a second Ig constant region or a portion thereof by an XTEN sequence in between, wherein the XTEN sequence of the second polypeptide contains less than 288 amino acid residues, and wherein the first polypeptide is linked to or associated with the second polypeptide.