CD44 BINDING PEPTIDES

摘要

The present invention relates to a protein which binds to the domain encoded by exon 9 of human CD44 (CD44ex9), to fusion proteins and conjugates of said protein and especially to nanoparticles conjugated to said protein. The invention further relates to a method of production for the protein and the respective conjugated nanoparticles and the use of the protein of the invention for treatment and diagnosis of cancer diseases.

主权项

1. A protein binding to a polypeptide encoded by exon 9 of human CD44 (CD44ex9), said protein comprises or consists of
(i) an amino acid sequence according SEQ ID No. 1 to 5 and SEQ ID No. 39 to 52; or (ii) an amino acid sequence with at least 90% identity to the amino acid sequence given in SEQ ID No. 1 to 5 and SEQ ID No. 39 to 52; or (iii) an amino acid sequence with 100% identity to the CD44-binding motif defined by the sequence: “PYYGKXLX3YLQPSFAVQVX2SXQX10-14AIE” as depicted in SEQ ID Nos. 6 to 10 or defined by the sequence: “PGLQPSFAVQVX2S/AXQX10-14AIE” as depicted in SEQ ID Nos. 53 to 62, wherein X denotes an arbitrary amino acid; and wherein said protein has a length of 100 amino acids or less.