Compositions of GM-CSF and Interleukin Fusions for Immune Modulation and Uses Related Thereto

摘要

This disclosure relates to recombinant proteins comprising a GM-CSF sequence and an interleukin sequence and nucleic acids related thereto. In certain embodiments, the disclosure relates to recombinant proteins comprises N-terminal sequences that are the result of improved production techniques and uses for treating or preventing autoimmune diseases such as multiple sclerosis and cancer.

主权项

1. A recombinant protein comprising
a) an N-terminal sequence selected from glycine-histidine amino acid sequence or a N-terminal serine-histidine amino acid sequence; b) a human GM-CSF sequence; and c) a human interleukin sequence.