发明名称 |
EPINEPHRINE NANOPARTICLES, METHODS OF FABRICATION THEREOF, AND METHODS FOR USE THEREOF FOR TREATMENT OF CONDITIONS RESPONSIVE TO EPINEPHRINE |
摘要 |
The invention provides a composition including epinephrine nanoparticles and methods for therapeutic use of the composition in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions. |
申请公布号 |
US2017071881(A1) |
申请公布日期 |
2017.03.16 |
申请号 |
US201615358743 |
申请日期 |
2016.11.22 |
申请人 |
NOVA SOUTHEASTERN UNIVERSITY |
发明人 |
RAWAS-QALAJI Mutasem;RACHID Ousama;SIMONS Keith John;SIMONS Estelle;NIEVES Enrique |
分类号 |
A61K31/137;A61K9/19;A61K9/00 |
主分类号 |
A61K31/137 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical composition comprising epinephrine nanoparticles. |
地址 |
Fort Lauderdale FL US |