BIOLOGICALLY RELEVANT ORTHOGONAL CYTOKINE/RECEPTOR PAIRS

摘要

Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided. Specifically, the disclosure provides a system for selective activation of a receptor in a cell, the system comprising: (a) an orthogonal receptor, which does not bind to its native ligand; and (b) an orthogonal cytokine, which (i) does not bind to its native receptor and (ii) binds to and activates the orthogonal receptor. Further disclosed are methods of using an engineered cell population for treating disorders.