Polyimidazoles for use as bile acid sequestrants

摘要

H:/grs/Interwoven/NRPortbl/DCC/GRS/32291501 .docx-24/02/2017 POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANT The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome diarrhea (IBS-D), bile acid malabsorption, and the like.