发明名称 |
RING CONSTRAINED DIARYLAMINO SULFONAMIDES AS ANTI-CANCER AGENTS |
摘要 |
A genus of arylsulfonamide derivatives of ring constrained diarylamino sulfonamide compounds is disclosed. The compounds are of the following genus:. The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a therapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed. |
申请公布号 |
WO2017044572(A1) |
申请公布日期 |
2017.03.16 |
申请号 |
WO2016US50692 |
申请日期 |
2016.09.08 |
申请人 |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI |
发明人 |
OHLMEYER, Michael;KASTRINSKY, David |
分类号 |
C07D309/14;A61K31/18;A61K31/351;A61K31/445;A61P35/00;C07C311/29;C07D211/56 |
主分类号 |
C07D309/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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