EXTRACTS OF CYCLANTHERA PEDATA AND FORMULATIONS AND USES THEREOF

摘要

The invention provides a method for extracting active therapeutic components from plant materials of the cyclanthera pedata plant which comprises immersing said plant material containing active components and selected from the group consisting of fruits, flowers, leaves, stems, twigs, bark, wood, buds, seeds, roots, and pods in a solvent for a period of time of about 30 minutes to about 10 hours to achieve transfer of active components from the plant material to the solvent, separating the solvent containing active components from the plant material, and evaporating or distilling the solvent to produce a concentrated fraction containing active components. The invention further includes compositions and therapeutic formulations of such extracts to treat hypercholesterolemia and other high lipid related diseases.

主权项

1. A solid-form extract derived from the fruit of cyclanthera pedata plants produced by a process comprising the following steps: (1) immersing the fresh fruit from said plant in an aqueous solution, solution containing an organic peracid for a period of time of about 2 minutes to 10 minutes, (2) cutting the fruit into strips and removing the seeds and mucilage form said strips, (3) drying said strips at a temperature between 10° C. and 80° C.; (4) milling said strips to produce a powder having a size of about 1 nm to about 2-10 mm; (5) Obtaining a concentrated liquid extract by immersing the milled material in a polar solvent including water, water-alcohol mixtures, alcohols, ethers, hydrocarbons or other organic solvents or mixtures thereof for a period of time of about 30 minutes to about 15 days and perform an extraction process based on one or a combination of the following procedures: maceration, percolation, soxhlet extraction, microwave assisted extraction, ultrasound assisted extraction, accelerated solvent extraction, enhanced solvent extraction, pulse electric field assisted extraction and steam distillation; (6) concentrating said liquid extracts between 20 to 80% solids (7) absorbing said extract in a carrier and dry the concentrate liquid extract using conventional air drying methods or oven method or flash drying method or steam drying or fluid bed or spray drying or vacuum or radiation drying method to yield a solid-form extract of Cyclanthera pedata.