Use of microparticles and endothelial cells with decellularized organs and tissues

摘要

The invention provides a method for maintaining capillary lumen diameter, reducing a decrease in capillary vessel lumen diameter or expanding capillary vessel lumen diameter in a re-endothelialised but otherwise decellularised organ or tissue graft with an intact extracellular matrix (ECM) vascular network. The method is based on administration of endothelial cells and microparticles to the decellularised ECM.