| 摘要 |
Abstract The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such 5 a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety e.g., cholesterol, is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents. 69105941 (GHMatters) P58751.AU.5 PETERB 17/09/15 w O==P-O 0- tethering attachment point (R-2) backbone attachment points carrier LIGAND RRMS o tether O=P-O' w FG' 0 .R=H; A: carrier R R= R = ('w -- )+ (LIGAND) B: carrier R C: - E R'O N(R")2 |
