| 发明名称 |
MODIFIED RELEASE DOXYCYCLINE COMPOSITION |
| 摘要 |
Doxycycline formulations with a reduced food effect are disclosed. Particularly disclosed are modified release formulations which can be administered once a day and exhibit a reduced food effect. Methods of treating inflammatory conductions such as rosacea or inflammatory symptoms such as the papules and pustules of rosacea or acne vulgaris are also disclosed. |
| 申请公布号 |
US2017071957(A1) |
申请公布日期 |
2017.03.16 |
| 申请号 |
US201615359292 |
申请日期 |
2016.11.22 |
| 申请人 |
Dr. Reddy's Laboratories Ltd. |
发明人 |
Baheti Ankit;Padhi Bijay Kumar;Raghuvanshi Rajeev Singh |
| 分类号 |
A61K31/65;A61K9/00;A61K9/48 |
主分类号 |
A61K31/65 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A modified release oral composition comprising:
i. doxycycline; ii. one or more water soluble and insoluble polymers; and iii. one or more pharmaceutically acceptable excipients;wherein said composition has dC/dT value of less than about 80% of the dC/dT value provided by the commercially available 40 mg doxycycline composition, measured in a single dose human pharmacokinetic study in a fasting state and in a time period of T0 min to T60 mins. |
| 地址 |
Hyderabad IN |
