POTENT INHIBITORS OF HUMAN CARBONIC ANHYDRASE II AND BOVINE CARBONIC ANHYDRASE II AND THEIR MECHANISM OF ACTION

摘要

Inhibitors of carbonic anhydrase-II derived from sulfanilamide are reported.

主权项

1. A compound with inhibitory activity against carbonic anhydrase-II enzyme selected from the group consisting of:
N-(4-Sulfamoylphenylcarbamothioyl)benzamide; 4-Chloro-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 4-Methyl-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 4-Nitro-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 3-Chloro-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 3-Nitro-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 2-Nitro-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 2-Phenyl-N-(4-sulfamoylphenylcarbamothioyl)acetamide; 2-Methyl-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 3-Methyl-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 3-Methoxy-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 4-Chloro-2-nitro-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 4-Fluoro-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 3,4,5-Trimethoxy-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 2-Chloro-4-nitro-N-(4-sulfamoylphenylcarbamothioyl)benzamide; 3,5-Dimethoxy-N-(4-sulfamoylphenylcarbamothioyl)benzamide; N-(4-Sulfamoylphenylcarbamothioyl)tetrahydrofuran-2-carboxamide; 2-Phenyl-N-(4-sulfamoylphenylcarbamothioyl)butanamide; and 2,4-Dichloro-N-(4(4-sulfamoylphenylcarbamothioyl)benzamide.