发明名称 |
SYNTHETIC ANTIBODIES TO BAX AND USES THEREOF |
摘要 |
Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N- terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX activation. Also disclosed are methods of using the Fabs for measuring inactive monomeric BAX levels, screening for small molecules that bind to an N-terminal activation site of BAX, inhibiting apoptotic cell death, and predicting the ability of a cancer therapy to promote apoptotic cell death. |
申请公布号 |
WO2017044308(A1) |
申请公布日期 |
2017.03.16 |
申请号 |
WO2016US48508 |
申请日期 |
2016.08.25 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.;THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO |
发明人 |
GAVATHIOTIS, Evripidis;LAI, Jonathan, R.;SIDHU, Sachdev |
分类号 |
C07K14/47;A61K38/17;A61K39/395;C07K16/00;G01N33/53 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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